| Date | Status | Player | Injury | Target Return? | Prognosis |
|---|
| 2012-06-13 | Injured-reserve | Martin Rucker | Knee | | is on injured reserve |
| 2012-06-13 | Questionable | Sidney Rice | Shoulder | | is questionable for the start of the season |
| 2012-05-25 | Questionable | Johnny Knox | Back | | is questionable for the start of the season |
| 2012-05-24 | Questionable | Hakeem Nicks | Foot | | is questionable for the start of the season |
| 2012-05-15 | Out | Darius Fleming | Knee | | is expected to miss the entire season |
| 2012-05-15 | Questionable | Terrance Knighton | Eye | | is questionable for the start of the season |
| 2012-05-11 | Out | Phil Taylor | Pectoral | | is out indefinitely |
| 2012-05-10 | Out | Da'Quan Bowers | Achilles | | is out indefinitely |
| 2012-05-08 | Questionable | Jamaal Charles | Knee | | is questionable for the start of the season |
| 2012-05-04 | Questionable | Terrell Suggs | Achilles | | is out indefinitely |
| 2012-05-01 | Doubtful | Casey Hampton | Knee | | is doubtful for the start of the season |
| 2012-05-01 | Doubtful | Rashard Mendenhall | Knee | | is doubtful for the start of the season |
| 2012-05-01 | Doubtful | Walter Thurmond III | Leg | | is doubtful for the start of the season |
| 2012-05-01 | Doubtful | Travis Beckum | Knee | | is doubtful for the start of the season |
| 2012-05-01 | Out | Johnnie Troutman | Pectoral | | is out indefinitely |
| 2012-05-01 | Out | Jason Peters | Achilles | | is out indefinitely |
| 2012-05-01 | Out | Adrian Peterson | Knee | | is out indefinitely |
| 2012-05-01 | Questionable | Michael Hoomanawanui | Knee | | is questionable for the start of the season |
| 2012-05-01 | Questionable | Leon Hall | Achilles | | is questionable for the start of the season |
| 2012-05-01 | Questionable | Mike Caussin | Knee | | is questionable for the start of the season |
| 2012-05-01 | Questionable | David Reed | Knee | | is questionable for the start of the season |
| 2012-05-01 | Questionable | Colt Anderson | Knee | | is questionable for the start of the season |
| 2012-05-01 | Questionable | Andre Brown | Four-game suspension | | will be eligible to return on 10/7 against Cleveland |
| 2012-05-01 | Questionable | Ryan Broyles | Knee | | is questionable for the start of the season |
| 2012-05-01 | Questionable | Andrew Quarless | Knee | | is questionable for the start of the season |
| 2012-05-01 | Questionable | Jon Beason | Achilles | | is questionable for the start of the season |
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